Office of the Vice President for Research

Monday Memo March 6, 2006

In this Issue

Vice President's Message
The Good, the Bad and the Ugly
Good News and Coming Events
News
Recent Results
Events
Opportunities and Sponsor Information
BNL-SBU Seed Grant Deadline
Applications for the Empire Clinical Research Investigators Program (ECRIP) Now Being Accepted
NIH Pathway to Independence (PI) Award
Stony Brook DARE Competition
U. S. Embassy Summer Jobs
Upcoming Funding Opportunities
Interdisciplinary Seminars
Music for Meetings
Change in Funding Opportunity Announcements That Use R03, R21, R33, and R34 Grant Mechanisms: Transition to Electronic Submission Using SF424 (R&R) Grant Application Package
NIH and Grants.gov: Registration
Grants.gov and Mac Users
Updates to NIH’s Electronic Application Submission Program Available Through Listserv Subscription
Establishment of Multiple Principle Investigator Awards at NIH
Essential Policies, Procedures and Resources
BNL Tuition Cost Recovery
New Edition of the Procurement Newsletter
SUNY Policies on the Web
For More Information

Vice President's Message

The Good, the Bad and the Ugly

There was good news and bad news for science researchers in the President's State of the Union address. On the plus side, the Advanced Competitiveness Initiative announced a "strong commitment to double over 10 years investment in key Federal agencies that support basic research programs in the physical sciences and engineering - the National Science Foundation (NSF), the Department of Energy's Office of Science (DoE SC), and the Department of Commerce's National Institute of Standards and Technology (NIST)." This appears to be good news for NSF, in the context of the agency's increase in the current year, which was too small to offset non-R&D costs, reducing real R&D funding for the third successive year, as well as the basic science portion of DOE, which has also faced fiscal severities that our BNL colleagues experienced directly last year. However, one must ask whether a President in his sixth year of office, with the lowest public approval ratings he has yet experienced, has the desire, the will and the capacity to make the kind of start toward this laudable goal during his few remaining years in office that would impel his successor(s) to complete. The bad news, of course, is for the agencies not identified as critical resources for economic competitiveness (by what calculus?) In the current year, the NIH budget remained flat, a de facto decrease for the first time since 1970, and the absolute aggregate dollar amount of NIH funds coming to all New York institutions dropped as well. Science at NASA, another significant supporter of physical sciences and engineering research and of our campus research enterprise, is being starved to pay for the development of new vehicles for human space flight. DOD, also a Stony Brook funder, would be one of the budget winners on the weapons side and one of the losers on the science and technology side. Overall, according to a preliminary analysis of the President's proposed FY2007 budget by the AAAS, the federal basic and applied research investment (excluding the "D" portion of "R&D") would decline 3.4%, to $54.7 billion, as the proposed physical sciences and related increases would be more than offset by cuts at the other agencies. This would be the third year of decline in a row after the peak of the 2004 fiscal year.

These conditions make even more important the efforts we are all making to collaborate on multi-disciplinary, multi-investigator opportunities. Please look here for a list of the current working groups and contact information for Associate Vice President for Research Martin Schoonen if you have an idea for a new initiative to start. If you are new to the enterprise, please come to the "Getting Your Proposal Out the Door" workshop so that you can get the essential logistical aspects of your submission under control and concentrate on the substance!

Good News and Coming Events

News

Please join us in rejoicing with colleagues for achievements that have become known since the last issue.

PHENIX Experiment at RHIC Publishes Three Papers in a Single Edition of Physical Review Letters

In a rare feat the Phenix Experiment at Brookhaven National Lab's Relativistic Heavy Ion Collider (RHIC) published three papers in the January 26 online edition of Physical Review Letters, one of the most prestigious journals in the physics field. The first paper derives the rate at which charm-quarks were produced during proton-proton collisions at RHIC. This information will be invaluable for assisting the development of theoretical models of charm-quark production in proton-proton collisions as well as serving as a baseline for seeking new phenomena in gold-gold collisions. The second paper used key measurements of electrons to determine the rates of charm- and bottom-quark production in gold-gold collisions--allowing scientists to conclude that these quarks under go much larger energy losses than predicted. The paper is critical because it challenges RHIC scientists' current understanding of gold-gold collisions. The third paper analyzes how certain particles move and interact as they fly away from the collision center and describes this movement in relation to ideas of "flow" that describe the fluid properties of matter created during the collisions. Stony Brook Professors Nuggehalli Ajitanand, Chemistry, John Alexander, Chemistry, Axel Drees, Physics and Astronomy, Thomas Hemmick, Physics and Astronomy, Barbara Jacak, Physics and Astronomy, Roy Lacey, Chemistry and Michael Marx, Physics and Astronomy, were among the over 300 co-authors of the papers.

Medicine/Pharmacology

The 13th Conference on Retroviruses and Opportunistic Infections, reported in the February 17 issue of Science, included a recent advance on HIA/AIDS with two important connections to Stony Brook. The most encouraging news at the meeting was reported to involve clinical trial results of a novel compound developed by Merck, MK-0518, that suggested its potential to be the first in a new class of integrase inhibiting anti-retroviral drugs that may block HIV replication by preventing the viral enzyme integrase from inserting HIV DNA into the human genome. Stony Brook Ph.D. Daria Hazuda (Pharmacological Sciences), Vice President of Virus and Cell Biology at Merck Research Laboratories, is the lead scientist for this drug development project and was first author of the papers in Science (e.g., 2004, 2000) describing the discovery and development of this class of drugs. Prof. Roy Steigbigel indicates that the University's HIV Treatment Development Center, where he is director, entered the first patient, and had the largest number of patients in the U.S., in the initial clinical study of MK-0518, and continues to study it as salvage therapy for patients whose virus is resistant to all currently available medications. The Science report noted a trial in which 80% of the participants, infected with multi-drug resistant HIV, showed a 99% drop in the replication of the virus.

Recent Results

Chemistry, Applied Mathematics and Statistics and the Center for Structural Biology

A team led by Carlos Simmerling of the Chemistry Department and also including Viktor Hornak, Center for Structural Biology, Asim Okur, Chemistry, and Robert C. Rizzo, Applied Mathematics and Statistics, have just published 2 articles that provide important new insight into HIV-1 protease, a key AIDS drug target. Existing studies had been unable to show how the protease opens, an event required for reproduction of the virus. To overcome this problem, the team used atomic-detail computer simulation methods developed in the Simmerling lab. The first article, "HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations," was published in the January 24 issue of the Proceedings of the National Academy of Sciences (PNAS - January 24, 2006, vol. 103, no. 4, 915-920). This reported for the first time how the protease opens and closes, providing the information needed to develop new drugs that interfere with this motion. A second article, "HIV-1 Protease Flaps Spontaneously Close to the Correct Structure in Simulations Following Manual Placement of an Inhibitor into the Open State" (Journal of the American Chemical Society - February 14, 2006, vol. 128, 2812-2813) showed how the protease closes around a drug that enters the active site, blocking function of the protease. In addition to the new AIDS insight, these studies represent a tremendous advance in the application of computer simulations to complex biological phenomena. Even more exciting work by the group is underway and further results will be posted here as they come in.

Events

Sponsored Programs Workshop

March 21: "Getting Your Proposal Out the Door"

9:30am-12:30pm Tuesday, March 21. HSC Level 2, Room 108
Issues covered include: Approval from your chair and dean; Use of hospital staff, patients or facilities; Matching/Cost sharing; Faculty from other departments; Percentage of effort on the 4-page form; Detailed overview of grants.gov process. To register: Please e-mail Joann Delucia-Conlon at-
Joann.DeLucia-Conlon@stonybrook.edu

The schedule for OVPR workshops is also on-line at- http://www.stonybrook.edu/research/new/seminar.html

 

 

Provost's Lecture Series

March 9: "Time, Fossils and Environments: Turkana's Place in the Human Story

Frank Brown, Dean of the University of Utah's College of Mines and Earth Sciences, is a key figure in African paleolithic archaeology. His analysis of the age and stratigraphy of deposits in Africa's Turkana Basin has made possible the dating of Kenyanthropus platyops and other hominid fossils from the area. Thursday, March 9, 4 p.m. Wang Center, Lecture Hall 2.

March 21: "Women in Academia: 21st Century Challenges"

Evelynn Hammonds is Senior Vice Provost for Faculty Development and Diversity at Harvard University. Abigail Stewart is Sandra Schwartz Tangri Professor of Psychology and Women’s Studies at the University of Michigan and director of the ADVANCE Project. Tuesday, March 21, 4 p.m Student Activities Center Auditorium



Wine Center

March 9: "Fresh Tastes: A Hint of Spring"

Greg Gove/Michael Meehan, Peconic Bay Winery Peconic Bay's winemaker Gove and executive chef Meehan are back by popular demand to offer a guided taste of Long Island's freshest food and wine pairings, delivered with a high level of excellence and down-to-earth entertainment. Learn what this emerging regional cuisine is all about with two of its most innovative and experienced creators. Thursday, March 9 6:30–8:00 p.m., $55

To Register:  Call Ginny Clancy at (631) 632-9404. Note: You must be 21 or over to participate in winetasting events. Reservations are required for all sessions.

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Opportunities and Sponsor Information

BNL-SBU Seed Grant Deadline

The deadline for this year’s RFP for BNL-SBU Seed Grants is March 10, 2006. For this eighth year, grants of up to $25k may be awarded. Please see the below site or call the Office of Brookhaven Affairs (631) 632-7010 for more information about the Grants and details about the application process.
http://ws.cc.stonybrook.edu/bnl/rfp.html

Applications for the Empire Clinical Research Investigators Program (ECRIP) Now Being Accepted

The program is open to MDs, PhDs and allied health care professionals interested in patient-oriented clinical research, epidemiologic and behavioral studies, outcomes research and health services research. Requirements for applicants include: must be a US citizen, national or permanent resident AND a graduate of a New York State medical, dental or podiatric school, a resident or graduate of a residency training program sponsored by a New York State institution, or reside in New York State. Participation is mandatory in the formal didactic training program provided by the School of Medicine through a NIH-funded K30 award to meet the clinical research training curriculum requirement of the ECRIP program. Upon successful completion of the formal didactic training program, participants will receive an Advanced Certificate in Clinical Research. The deadline for submission of a research proposal to the GCRC Advisory Committee, detailing the area of interest, data, methodology, expected outcomes and sponsor/mentor information is March 30, 2006. Details concerning this program can be found on the New York State's Department of Health's GME website at http://www.nyhealth.gov/nysdho/gme/main

--Contributed by: Marjorie Lundgren, Program Coordinator 6-9004 or mlundgren@notes.cc.sunysb.edu

NIH Pathway to Independence (PI) Award

The NIH Pathway to Independence Award is an innovative, new program that will provide an opportunity for promising postdoctoral scientists to receive both mentored and independent research support from the same award.

NIH plans to issue between 150 and 200 awards for this program in the first year, and for the each of the next five years, amounting to approximately $390 million. The actual number and distribution of awards made by the NIH Institutes and Centers will depend upon the quality of the applications received and the results of the scientific peer review process.

The Pathway to Independence Award will provide up to five years of support consisting of two phases. The initial phase will provide 1-2 years of mentored support for highly promising, postdoctoral research scientists. This phase will be followed by up to 3 years of independent support contingent on securing an independent research position. Award recipients will be expected to compete successfully for independent R01 support from the NIH during the career transition award period. The PI Award is limited to postdoctoral trainees who propose research relevant to the mission of one or more of the participating NIH Institutes and Centers.

The subsequent application for the independent phase may be submitted on behalf of the awardee (principal investigator) by any domestic for-profit or non-profit institution/organization such as universities, colleges, hospitals and laboratories at which the awardee has been recruited. Agencies of the Federal government (including NIH intramural laboratories) and foreign institutions are not eligible to apply for the independent phase of the PI award.

Eligible Principal Investigators include outstanding postdoctoral candidates who have terminal clinical or research doctorates (including Ph.D., M.D., D.O., D.C., N.D., D.D.S., D.V.M., Sc.D., D.N.S. or equivalent doctoral degrees) who have no more than 5 years of postdoctoral research training at the time of initial application or resubmission(s).

Application Receipt Dates(s): April 7, 2006 then standard dates, please see
http://grants.nih.gov/grants/funding/submissionschedule.htm      for details.
The complete text of the announcement can be found at:
http://grants.nih.gov/grants/guide/pa-files/PA-06-133.html

Stony Brook DARE Competition

Stony Brook's DARE Competition encourages students at all levels in the University community to act on their talent, ideas and energy to create the next generation of Googles, Palms and OSI Pharmaceuticals, right here on Long Island. Still a start-up in its second year, DARE, allied with the National Science Foundation Partnerships for Innovation program on campus, will award $10,000 each to the two teams of student entrepreneurs whose business plans for new technology-based ventures show the greatest ingenuity and potential.

Please pass on information about this contest to your students or whomever may be interested or in a position to spread the word. The deadline for submission is May 3, 2006. For more information go to the DARE website.

U. S. Embassy Summer Jobs

The Foreign Agricultural Service's International Internship Program provides college students the opportunity to live and work in a paid internship at an American Embassy overseas. Through work assignments participants learn various aspects of international trade, trade policy, international relations, diplomacy, regional and cultural considerations, etc. Positions are available in Western Europe, Latin America, and Asia. The internship is offered every semester and summer for graduate students and upperclassmen (juniors and seniors). Requirements: Be a currently enrolled graduate or undergraduate student (must be a junior or a senior), a U.S.citizen and in good academic standing. Graduate level students in business, international relations, regional studies (i.e. Latin American Studies, Asian Studies, etc), public policy, foreign languages, etc., as well as high-achieving junior and senior undergraduates in similar majors are particularly encouraged to apply, though the program is open to all majors. The deadline has been extended to March 15. This internship program is a great way to get international experience and exposure to career fields you may have never considered. Please see the application at this website:
http://www.fas.usda.gov/admin/student /summerintern.htm

If paying for your own transportation to your job site is a financial problem, still apply and we'll see how we can find you financial assistance. Please pass this email on to any other students or listservs.

--Contributed by Lillian Gorman Program Analyst, USDA Hispanic Serving Institutions National Program 1400 Independence S.W., Rm. 3912-S Washington, D.C.20250 202) 720- 6506 (phone) (202) 720-5336 (fax) lgorman@ars.usda.gov

Upcoming Funding Opportunities

For a complete list of upcoming deadlines, please go to -
http://www.stonybrook.edu/research/fndopp/deadlcal.html

Interdisciplinary Seminars

Please remember that, in an effort to encourage interdisciplinary research on campus, this office will supply $100 toward a speaker's luncheon when your department invites a Stony Brook colleague from an unrelated discipline to give a seminar. Please contact Ann-Marie Scheidt amscheidt@notes.cc.sunysb.edu to determine eligibility. You will be asked to provide a copy of the seminar notice annotated with the number of attendees and a brief description of any anticipated collaborations with the speaker's department.

Music for Meetings

Please remember that the OVPR would like to assist those of you who are planning a research meeting on campus by providing musical interludes. If you would like to have Stony Brook student musicians play at the reception for your meeting it can be arranged by contacting Ann-Marie Scheidt amscheidt@notes.cc.sunysb.edu. OVPR will make a payment to the Department of Music and the Department in turn pays the students. You get to listen to some nice music.

Change in Funding Opportunity Announcements That Use R03, R21, R33, and R34 Grant Mechanisms: Transition to Electronic Submission Using SF424 (R&R) Grant Application Package

The NIH, CDC and AHRQ have issued a Notice, NOT-OD-06-046, to announce the following changes regarding funding opportunity announcements (FOA's) that utilize the Small Research Grant (R03), Exploratory/Developmental Research Grant (R21), the Phased Innovation Award (R21/R33), and the NIH Clinical Trial Planning Grant (R34) mechanisms.

Effective June 1, 2006, R03 and R21 paper applications will no longer be accepted by the NIH, AHRQ or CDC. See http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-067.html
The agencies are transitioning to electronic submission on the SF424 Research and Research Related (R&R) application form through Grants.gov by mechanism, which requires that we expire and/or issue separate FOAs for each mechanism to accommodate the new process. The use of “parent” FOAs will provide a means for standardizing the R03 and R21 application characteristics, requirements, preparation, and review procedures. These parent announcements accommodate investigator-initiated (unsolicited) applications and allow Institutes/Centers (ICs)/Agencies to describe how they use each mechanism and highlight their specific areas of scientific interest within a single FOA. Note, currently, there is not a Parent R34 FOA; each IC plans to issue separate R34 announcements.

The FOAs identified are grouped in three categories according to the current plan of action. Any changes from the current plan will be reflected on individual FOAs.

1.  Those that expired effective March 2, 2006.
2.  Those for which the Parent R03 and Parent R21 FOA's now include the scientific opportunities from currently published FOAs. Note: There will not be a Parent R34. Each IC will issue separate R34 announcements.
3.  Those reissued on or after March 2, 2006.

Where noted, R01 and other mechanisms that have not transitioned to electronic grant submission will continue to be accepted by the NIH in response to the FOA's shown in the Notice, but applicants MUST use the PHS 398 application in paper format until the mechanism transitions to the SF424 (R&R) electronic format. See:
http://era.nih.gov/ElectronicReceipt/files/timeline_adjustments_to_r01.htm

Specifically, R01 applications must be submitted electronically effective February 1, 2007 for new applications and March 1, 2007 for resubmission, competing renewal, and supplemental applications. The current schedule and other important information related to NIH’s transition from the PHS398 paper application to the SF424 (R&R) electronic application is available at:
http://era.nih.gov/ElectronicReceipt/

See http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-046.html
for the full text of the Notice
.

Over time, NIH will transition all funding mechanisms to the SF424 (R&R) form and electronic submission through Grants.gov. For now we are seeking to bring individual mechanisms into this new unified process in a measured way to ensure that the NIH can accept the applications without difficulty and that institutions/organizations have time to experience the new electronic ways of doing business.

--Contributed by Peter Saal, Director, Research Resources Center

NIH and Grants.gov: Registration

While Principal Investigators (PIs) do not have to register with Grants.gov  – that registration is institutional –  the individual designated as the PI on the application must be registered in the eRA Commons. The registration process can take several weeks, especially when close to submission dates when registration volume peaks. NIH recommends starting four weeks ahead of your target submission date. PI registration must be done by an Office of Sponsored Programs official at Stony Brook who is already registered in the eRA Commons.

Each funding opportunity announcement (program announcement/request for application (PA/RFA)) includes an application package with an application guide (sample guide). This document is critical to submitting a complete and accurate application to NIH. There are fields within the SF424 (R&R) components that are not marked as mandatory on the federal-wide form but that are required by NIH (e.g., the Credential field of the R&R Senior/Key Person Profile component must contain the PI's assigned eRA Commons User ID). Agency-specific instructions for such fields are clearly identified in the application guide. The funding opportunity announcement to which you are applying also may include guidance on application submission. Taking advantage of these resources will save you time in the long run by avoiding the need to correct errors and resubmit your application.

SF424 (R&R) application guides, sample application packages and related resources at-
http://grants2.nih.gov/grants/forms.htm

Grants.gov for Mac OS X

Grants.gov is the new unified clearinghouse for all federal grant opportunities from all federal agencies that manage grant funds. Grants.gov currently uses a Windows-only solution for electronic grant submission. The PureEdge viewer is required to complete grant application packages and, at this time, there is no native Macintosh PureEdge client. IBM has acquired PureEdge, and now calls the product IBM Workplace Forms; IBM plans to add Mac support in the future and Grants.gov has committed to providing a cross-platform solution by November 2006. In the interim, Grants.gov, in conjunction with NIH, has created a Citrix server solution that allows Mac OS X users to complete their application packages and submit them electronically using Mac OS X.

The University of Wisconsin has created a single preconfigured package for Mac OS X users to access this solution. This package is provided to the community as a service by the University of Wisconsin, and is not an official product of Grants.gov. The University of Wisconsin cannot provide support for this solution.
The platform can be found here:
http://apple.doit.wisc.edu/grants.gov/

--Contributed by Peter Saal, Director, Research Resources Center

Updates to NIH’s Electronic Application Submission Program Available Through Listserv Subscription
The Office of Extramural Research has established a listserv electronic mailing list to provide periodic updates on its electronic grant application program to scientists and administrators in the biomedical research community. Persons interested in receiving these updates are encouraged to subscribe to the appropriate listserv, as follows:

Scientists, Researchers and Principal Investigators: leaving the subject line blank, send a plain text email message to Listserv@list.nih.gov including only the words Subscribe NIH_eSUB_PI-L in the body of the message. The subject line should be blank.

Institutional Officials, Administrative and Business Personnel: leaving the subject line blank, send a plain text email message to Listserv@list.nih.gov including only the words Subscribe NIH_eSUB_AOR_SO-L in the body of the message.

--Contributed by Peter Saal, Director, Research Resources Center

Establishment of Multiple Principal Investigator Awards for the Support of Team Science Projects at NIH

In 2006 the National Institutes of Health (NIH) will begin to implement a Federal-wide policy to allow formally more than one Principal Investigator (PI) on individual research awards. This presents a new and important opportunity for investigators seeking support for projects or activities that clearly require a “team science” approaches and which do not fit the single-PI model. The multiple-PI model is intended to supplement, and not to replace, the traditional single PI model. The overarching goal is to encourage collaboration among equals when that is the most appropriate way to address a scientific problem.  Although the number of applications submitted with more than one PI is expected to be relatively small compared with those that continue to use the traditional single-PI format, we know that the impact on multidisciplinary efforts may be great. 

The NIH will make the multiple-PI option available for applications submitted in response to a selected group of Requests for Applications (RFAs) and Program Announcements (PAs) with May-June 2006 receipt dates.  It is likely that additional initiatives will be selected to pilot this activity for receipt dates in the October time frame.  Based on experience from these pilot initiatives, it is expected that the multiple-PI option will become available for most investigator-initiated research grant mechanisms submitted for January 2007 and later application receipt dates. The NIH will announce those specific RFAs and PA selected to pilot the multi-PI option as well as future plans for expansion to other mechanisms in the NIH Guide to Grants and Contracts at
http://grants.nih.gov/grants/guide/index.html#search.

A Multiple Principal Investigator website (http://grants.nih.gov/grants/multi_pi/) has been created to provide general information on the new policy.  This includes: background and features of the multiple-PI policy; major issues to be considered in its implementation; PI roles and responsibilities; distribution of credit; allocation of funds; and awards to more than one institution.  Much of this information is located in the “Frequently Asked Questions” (FAQ) section of the web site.  Many of the questions listed in the FAQ section are based on communications received in response to Requests for Information (RFI) published by the NIH and by the Office of Science and Technology Policy, Executive Office of the President.  Results from these RFIs are also available at the Multiple Principal Investigator web site.  There has been additional outreach to the scientific community through a recently published article in “NIH Extramural Nexus,” (http://grants2.nih.gov/grants/nexus.htm) the NIH’s bimonthly extramural update that is available free to all who request it.

Many procedures for implementation of the policy to recognize formally multiple PIs on individual research awards are still in the planning stages, and the NIH looks forward to continued input from the scientific community. All potential applicants are encouraged to access the NIH Guide for Grants and Contracts for official notice(s).
For additional information please feel free to send email to multi_PI@mail.nih.gov.

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Essential Policies, Procedures and Resources

BNL Tuition Cost Recovery

Graduate student tuition cost recovery has been extended to SBU students supported by BNL researchers. A memo from the Provost describing the policy can be found here.

--Contributed by Robert McGrath, Provost and Vice President for Brookhaven Affairs

New Edition of the Procurement Newsletter

The March 2006 edition of the Procurement Office Newsletter, "Procurement News" and the 05/06 Lapsing Funds Calendar is  available for your viewing. You may access the newsletter at the Procurement website at
http://www.stonybrook.edu/procurement/news/

--Contributed by Christine Wilson, Procurement

SUNY Policies on the Web

SUNY recently created a section on its Website where all system-wide policies may be accessed. This library contains University-wide policies, procedures and related forms. They are organized here to provide information to all University employees. For policies and procedures specific to a campus, contact that campus directly. The site may be found at–
http://www.suny.info/policies/groups/public/documents/system/pub_source_0009.htm

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For More Information

An abundance of specific information for the research community is available on our Website, where past issues of this bulletin can also be found.

Office of the Vice President for Research - http://www.stonybrook.edu/research/

Monday Memo archive - http://www.stonybrook.edu/research/monmemo/mmarchive.html

All past issues of Monday Memo are keyword searchable.

And if you are challenged by the embarrassment of riches in the over 2,000 individual Web pages that comprise the Website, you may find the alphabetical site index helpful. The index can be accessed at
http://www.stonybrook.edu/research/sitemap.html.

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